Typhoid fever, also acknowledged as Salmonella Typhi or just Typhoid, is a worldwide common illness that transmits by ingestion of water or food contaminated with feces of an infected person. Then the bacteria Salmonella Typhi perforate through the wall of the intestinal and phagocytes by macrophages and alerts its structure to enforce their existence within the macrophage.
In this point, the bacteria start damaging the immune response and diminish the body resistance against harmful outer bodies. The organism then starts to spread through the lymphatics inside the macrophages and gets access in the reticuloendothelial system and many other organs all through the body. This gram-negative organism is a short bacillus and grows best at a human body temperature of 37 °C/99 °F.
Symptoms of Typhoid Fever: Typhoid fever is typified by a gradually progressive fever up to 40 °C (104 °F), gastroenteritis, profuse sweating and nonbloody diarrhea. Rash of flat or pink-colored spots may also appear less commonly.
An untreated typhoid fever usually contains four individual weeks that lasts for around one week each.
First Stage of Typhoid Fever: During the first week, the patient will experience a slowly rising temperature along with relative headache, cough, bradycardia and malaise. In many cases, a bloody nose or abdominal pain can also be found. During this period, the number of circulating blood cells starts to decrease which results leucopenia and also the tendency of eosinopenia and associated lymphocytosis can be experienced. However, during the first week, the result of traditional Widal test appears negative.
Second Stage of Typhoid Fever: The patient gets prostrated with high fever, about 40 °C (104 °F), during the 2nd week of infection. Frequent up and down of the intensity of the fever and sometimes being agitated is a good indication of typhoid fever. During this time, rose sports start appearing on the abdomen and lower chest of around one third of the patients. Diarrhea can also occur in this period: six to eight times in a day, green colored with a featured smell like pea-soup. The liver and spleen get enlarge (hepatosplenomygaly) and elevation of liver transaminases occurs during this period as well. This time, the Widal reaction goes strappingly positive with antiH and antiO antibodies and blood cultures may also be found positive during this stage. The most identifiable symptom of the typhoid fever is it usually grows in the afternoon up to the 1st and 2nd week of infection.
Third Stage of Typhoid Fever: A number of complications may occur during the third week of this disease. Because of bleeding in crammed Peyer’s patches, intestinal hemorrhage can occur which can be very dangerous but not fatal usually. Intestinal damage in distal ileum is another serious complication which is frequently fatal and can occur without any alarming symptoms until diffuse peritonitis or septicaemia sets in. Other complications include encephalitis, cholecysititis, metastatic abscesses, osteitis, endocarditis, and many more.Watch Full Movie Online Streaming Online and Download
The fever still goes high and swings less over a 24 hours time cycle. Dehydration continues and the patient remains delirious. The fever starts reducing by the end of 3rd week. This continues over the fourth and last week as well.